The CB1 receptor, is found throughout the nervous system, but is most densely found in the brain. It is due to this density in the brain that the receptor is responsible for the high associated with THC. It is also responsible for much of the pain relief attributed to cannabis, particularly nerve pain, for conditions such as Phantom Limb Pain, Complex Regional Pain Syndrome, and damage to the spine, such radiculopathy from herniated discs or spondylosis. Its other positive effects include enhancing appetite, and inducing and improving sleep.
The effects on appetite (aka “The Munchies”) are well established and for certain individuals allows them to maintain or even gain weight in difficult circumstances, such as when fighting the nausea of chemotherapy or HIV treatments.
The effects on sleep are particularly interesting in that it has been observed anecdotally that it can suppress vivid dreaming, which is gaining importance and research funding as US Combat Veterans with PTSD are widely reporting success in reducing, or even eliminating nightmares. It is already in use for this in Israel, where research and Medical Cannabis use is more advanced than elsewhere.