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Research

The Grass Might Be Greener: Medical Marijuana Patients Exhibit Altered Brain Activity and Improved Executive Function after 3 Months of Treatment.

AbstractThe vast majority of states have enacted full or partial medical marijuana (MMJ) programs, causing the number of patients seeking certification for MMJ use to increase dramatically in recent years. Despite increased use of MMJ across the nation, no studies thus far have examined the specific impact of MMJ on cognitive function and related brain activation. In the present study, MMJ pat...
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CLEAR and GroGlo Establish First UK Clinical Trials on Cannabis for Chronic Pain.

CLEAR has formed a partnership with the research arm of GroGlo, a UK-based manufacturer of high power, LED, horticultural grow lighting.The plan is to grow cannabis under a Home Office licence for the production of cannabis oil, both as a dietary supplement and for the development of medical products.  To begin with, a low-THC crop of industrial hemp will be planted.  We will be using th...
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Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson’s disease

BACKGROUND AND PURPOSE Previous findings have indicated that a cannabinoid, such as Δ9-THCV, which has antioxidant properties and the ability to activate CB2 receptors but to block CB1, might be a promising therapy for alleviating symptoms and delaying neurodegeneration in Parkinson's disease (PD).EXPERIMENTAL APPROACH The ability of Δ9-THCV to reduce motor inhibition and provide neuroprotec...
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Cannabinoids in the management of chronic pain: a front line clinical perspective.

Author: Mary E. LynchAbstract Chronic pain is an escalating public health problem. Currently available treatments are inadequate to control chronic pain conditions, and there is a critical need for novel treatments. Over a half century of elegant preclinical research has identified the presence of a sophisticated endocannabinoid system that is part of our natural pain and immune defense netwo...
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PRNewswire: Marijuana Derivative Reduces Seizures in Children and Young Adults with Treatment-Resistant Epilepsy

NEW YORK, Dec. 23, 2015 /PRNewswire-USNewswire/ -- Cannabidiol (CBD), a medical marijuana derivative, was effective in reducing seizure frequency and well-tolerated and safe for most children and young adults enrolled in a year-long study led byepilepsy specialists at NYU Langone Medical Center.These latest findings provide the first estimates of safety, tolerability and efficacy of prescr...
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The endocannabinoid system and pain.

Authors: Guindon J1, Hohmann AG. AbstractThe therapeutic potential of cannabinoids has been the topic of extensive investigation following the discovery of cannabinoid receptors and their endogenous ligands. Cannabinoid receptors and their endogenous ligands are present at supraspinal, spinal and peripheral levels. Cannabinoids suppress behavioral responses to noxious stimulation and suppress n...
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The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: A preliminary randomized, double-blind, placebo-controlled cross-over design study.

Authors: Jetly R1, Heber A2, Fraser G3, Boisvert D3. AbstractOBJECTIVE: Investigate the efficacy of nabilone capsules (NAB) in reducing the frequency and intensity of nightmares in subjects with PTSD. PATIENTS AND METHODS: Canadian male military personnel with PTSD, who despite standard treatment continued to experience trauma-related nightmares, received double-blind treatment with 0.5mg ...
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Medical Marijuana for Treatment of Chronic Pain and Other Medical and Psychiatric Problems A Clinical Review

Paper Authored by Kevin P. Hill, MD, MHSFull article available  here  and published in JAMA June 23/30, 2015, Vol 313, No. 24Of significant note is the conclusion, citing High Quality Evidence. Abstract Importance  As of March 2015, 23 states and the District of Columbia had medical marijuana laws in place. Physicians should know both the scientific rationale and the practical implications for...
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Medical Marijuana for Treatment of Chronic Pain and Other Medical and Psychiatric Problems A Clinical Review

Original source is Journal of the American Medical Society June 23/30, 2015, Vol 313, No. 24  Abstract Importance  Cannabis and cannabinoid drugs are widely used to treat disease or alleviate symptoms, but their efficacy for specific indications is not clear.Objective  To conduct a systematic review of the benefits and adverse events (AEs) of cannabinoids.Data Sources  Twenty-ei...
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