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morphine

Stuff: Helen Kelly: ‘My back is broken and I only have months to live but I’m pain free

Tumours have broken Helen Kelly's back and she only has months to live but illegally taking cannabis means she's pain free.The former Council of Trade Unions president was diagnosed with terminal lung cancer in February last year and was initially given about seven weeks to live."I am going to die very soon, there's no cure, it's grown like crazy."Almost 18 months later Kelly s...
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Low-Dose Cannabinoid Type 2 Receptor Agonist Attenuates Tolerance to Repeated Morphine Administration via Regulating μ-Opioid Receptor Expression in Walker 256 Tumor-Bearing Rats.

Authors:  Zhang M, Wang K, Ma M, Tian S, Wei N, Wang G. Abstract BACKGROUND: Morphine is widely used in patients with moderate and severe cancer pain, whereas the development of drug tolerance remains a major problem associated with opioid use. Previous studies have shown that cannabinoid type 2 (CB2) receptor agonists induce morphine analgesia, attenuate morphine tolerance in normal and neu...
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Cannabinoid Receptor-Specific Mechanisms To Ameliorate Pain In Sickle Cell Anemia Via Inhibition Of Mast Cell Activation And Neurogenic Inflammation

Authors: Lucile Vincent, Derek Vang, Julia Nguyen, Barbara Benson, Jianxun Lei, Kalpna Gupta. Abstract Sickle cell anaemia is a manifestation of a single point mutation in haemoglobin, but inflammation and pain are the insignia of this disease which can start in infancy and continue throughout life. Earlier studies showed that mast cell activation contributes to neurogenic inflammation and pain in...
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