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inflammation

Marijuana-derived Δ-9-tetrahydrocannabinol suppresses Th1/Th17 cell-mediated delayed-type hypersensitivity through microRNA regulation.

Abstract∆9-Tetrahydrocannabinol (THC) is one of the major bioactive cannabinoids derived from the Cannabis sativa plant and is known for its anti-inflammatory properties. Delayed-type hypersensitivity (DTH) is driven by proinflammatory T helper cells including the classic inflammatory Th1 lineage as well as the more recently discovered Th17 lineage. In the current study, we investigated whet...
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GPR55 – a putative “type 3” cannabinoid receptor in inflammation.

Authors: Yang H, Zhou J, Lehmann C.AbstractG protein-coupled receptor 55 (GPR55) shares numerous cannabinoid ligands with CB1 and CB2 receptors despite low homology with those classicalcannabinoid receptors. The pharmacology of GPR55 is not yet fully elucidated; however, GPR55 utilizes a different signaling system and downstream cascade associated with the receptor. Therefore, GPR55 has ...
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Cannabinoid Receptor-Specific Mechanisms To Ameliorate Pain In Sickle Cell Anemia Via Inhibition Of Mast Cell Activation And Neurogenic Inflammation

Authors: Lucile Vincent, Derek Vang, Julia Nguyen, Barbara Benson, Jianxun Lei, Kalpna Gupta. Abstract Sickle cell anaemia is a manifestation of a single point mutation in haemoglobin, but inflammation and pain are the insignia of this disease which can start in infancy and continue throughout life. Earlier studies showed that mast cell activation contributes to neurogenic inflammation and pain in...
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Cannabis Study: Full-Spectrum Cannabis Extracts More Medically Effective than CBD Alone

Cannabidiol (CBD) has been the focus of many medical cannabis studies, and continues to prove itself as a powerful anti-inflammatory drug. What makes CBD even more desirable for some patients is that it does not cause the psychoactive effects associated with tetrahydrocannabinol (THC).An extremely interesting study (Overcoming the Bell-Shaped Dose-Response of Cannabidiol by using Cannabis ...
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