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endocannabinoid

Research: Indirect modulation of the endocannabinoid system by specific fractions of nutmeg total extract.

AbstractCONTEXT: Nutmeg [Myristica fragrans Houtt. (Myristicaceae)] has a long-standing reputation of psychoactivity. Anecdotal reports of nutmeg use as a cheap marijuana substitute, coupled to previous studies reporting a cannabimimetic-like action, suggest that nutmeg may interact with the endocannabinoid system. OBJECTIVE: The study evaluates nutmeg fractions for binding capacity with va...
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Biased Type 1 Cannabinoid Receptor Signalling Influences Neuronal Viability in a Cell Culture Model of Huntington Disease.

Author: Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM. AbstractHuntington disease (HD) is an inherited, autosomal dominant, neurodegenerative disorder with limited treatment options. Prior to motor symptom onset or neuronal cell loss in HD, levels of the type 1 cannabinoid receptor (CB1) decrease in the basal ganglia. Decreasing CB1 levels are strongly correlated with chorea and cogn...
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Our Story – DIPG Brain Tumor

DIPG Brain tumor
 My beautiful one and only Granddaughter was born on the first day of spring 2010 and I was thrilled, scared, overjoyed, nervous, and oh so very much in love from the first time I set eyes on her. My daughter just 19 years old, back at home with me after having left her partner. It is now 2015 and my wee granddaughter is 5 years old and has brain cancer.This year has been a total trai...
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