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Low-Dose Cannabinoid Type 2 Receptor Agonist Attenuates Tolerance to Repeated Morphine Administration via Regulating μ-Opioid Receptor Expression in Walker 256 Tumor-Bearing Rats.

Authors:  Zhang M, Wang K, Ma M, Tian S, Wei N, Wang G. Abstract BACKGROUND: Morphine is widely used in patients with moderate and severe cancer pain, whereas the development of drug tolerance remains a major problem associated with opioid use. Previous studies have shown that cannabinoid type 2 (CB2) receptor agonists induce morphine analgesia, attenuate morphine tolerance in normal and neu...
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Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice.

Authors: Verty AN, Stefanidis A, McAinch AJ, Hryciw DH, Oldfield B. AbstractThe cannabinoid receptor 2 (CB2) is well known for its immune modulatory role. However, recent localisation of CB2 receptors in metabolically active tissue suggests that the CB2 receptor plays a significant role in energy homeostasis. This study was designed to investigate the impact of chronic CB2 receptor stimulation ...
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Biased Type 1 Cannabinoid Receptor Signalling Influences Neuronal Viability in a Cell Culture Model of Huntington Disease.

Author: Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM. AbstractHuntington disease (HD) is an inherited, autosomal dominant, neurodegenerative disorder with limited treatment options. Prior to motor symptom onset or neuronal cell loss in HD, levels of the type 1 cannabinoid receptor (CB1) decrease in the basal ganglia. Decreasing CB1 levels are strongly correlated with chorea and cogn...
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Cannabinoid Receptor-Specific Mechanisms To Ameliorate Pain In Sickle Cell Anemia Via Inhibition Of Mast Cell Activation And Neurogenic Inflammation

Authors: Lucile Vincent, Derek Vang, Julia Nguyen, Barbara Benson, Jianxun Lei, Kalpna Gupta. Abstract Sickle cell anaemia is a manifestation of a single point mutation in haemoglobin, but inflammation and pain are the insignia of this disease which can start in infancy and continue throughout life. Earlier studies showed that mast cell activation contributes to neurogenic inflammation and pain in...
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The endocannabinoid system and pain.

Authors: Guindon J1, Hohmann AG. AbstractThe therapeutic potential of cannabinoids has been the topic of extensive investigation following the discovery of cannabinoid receptors and their endogenous ligands. Cannabinoid receptors and their endogenous ligands are present at supraspinal, spinal and peripheral levels. Cannabinoids suppress behavioral responses to noxious stimulation and suppress n...
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The endocannabinoid system and cancer: therapeutic implication

Authors: Josée Guindon and Andrea G Hohmann AbstractThe endocannabinoid system is implicated in a variety of physiological and pathological conditions (inflammation, immunomodulation, analgesia, cancer and others). The main active ingredient of cannabis, Δ9-tetrahydrocannabinol (Δ9-THC), produces its effects through activation of CB1 and CB2 receptors. CB1 receptors are expressed at high leve...
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