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CB1

Biased Type 1 Cannabinoid Receptor Signalling Influences Neuronal Viability in a Cell Culture Model of Huntington Disease.

Author: Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM. AbstractHuntington disease (HD) is an inherited, autosomal dominant, neurodegenerative disorder with limited treatment options. Prior to motor symptom onset or neuronal cell loss in HD, levels of the type 1 cannabinoid receptor (CB1) decrease in the basal ganglia. Decreasing CB1 levels are strongly correlated with chorea and cogn...
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The endocannabinoid system and pain.

Authors: Guindon J1, Hohmann AG. AbstractThe therapeutic potential of cannabinoids has been the topic of extensive investigation following the discovery of cannabinoid receptors and their endogenous ligands. Cannabinoid receptors and their endogenous ligands are present at supraspinal, spinal and peripheral levels. Cannabinoids suppress behavioral responses to noxious stimulation and suppress n...
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The endocannabinoid system and cancer: therapeutic implication

Authors: Josée Guindon and Andrea G Hohmann AbstractThe endocannabinoid system is implicated in a variety of physiological and pathological conditions (inflammation, immunomodulation, analgesia, cancer and others). The main active ingredient of cannabis, Δ9-tetrahydrocannabinol (Δ9-THC), produces its effects through activation of CB1 and CB2 receptors. CB1 receptors are expressed at high leve...
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