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Cannabinoids

Attitudes of Israeli Rheumatologists to the Use of Medical Cannabis as Therapy for Rheumatic Disorders.

AbstractBACKGROUND: While medical cannabis has been used for thousands of years in the treatment of pain and other symptoms, evidence-based use is limited and practitioners face multiple areas of uncertainty regarding the rational use of these compounds. Nonetheless, an increasing public interest and advocacy in favor of medical cannabis is causing the issue to be encountered ever more freque...
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Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

Author: Ethan B Russo Abstract Tetrahydrocannabinol (THC) has been the primary focus of cannabis research since 1964, when Raphael Mechoulam isolated and synthesized it. More recently, the synergistic contributions of cannabidiol to cannabis pharmacology and analgesia have been scientifically demonstrated. Other phytocannabinoids, including tetrahydrocannabivarin, cannabigerol and cannabichromen...
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Controlled release tablet formulation containing natural Δ9-tetrahydrocannabinol.

Authors: Punyamurthula NS, Hingorani T, Adelli G, Gul W, ElSohly MA, Repka MA, Majumdar S AbstractCannabinoids are increasingly being used in the treatment of chemotherapy-induced nausea and vomiting (CINV) because of their action on thecannabinoid receptors, CB1 and CB2. The currently marketed capsule formulations (sesame oil based and crystalline powder) are required to be administered freque...
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The endocannabinoid system and pain.

Authors: Guindon J1, Hohmann AG. AbstractThe therapeutic potential of cannabinoids has been the topic of extensive investigation following the discovery of cannabinoid receptors and their endogenous ligands. Cannabinoid receptors and their endogenous ligands are present at supraspinal, spinal and peripheral levels. Cannabinoids suppress behavioral responses to noxious stimulation and suppress n...
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Medical Marijuana for Treatment of Chronic Pain and Other Medical and Psychiatric Problems A Clinical Review

Paper Authored by Kevin P. Hill, MD, MHSFull article available  here  and published in JAMA June 23/30, 2015, Vol 313, No. 24Of significant note is the conclusion, citing High Quality Evidence. Abstract Importance  As of March 2015, 23 states and the District of Columbia had medical marijuana laws in place. Physicians should know both the scientific rationale and the practical implications for...
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Medical Marijuana for Treatment of Chronic Pain and Other Medical and Psychiatric Problems A Clinical Review

Original source is Journal of the American Medical Society June 23/30, 2015, Vol 313, No. 24  Abstract Importance  Cannabis and cannabinoid drugs are widely used to treat disease or alleviate symptoms, but their efficacy for specific indications is not clear.Objective  To conduct a systematic review of the benefits and adverse events (AEs) of cannabinoids.Data Sources  Twenty-ei...
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